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KMID : 0043320100330121933
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Archives of Pharmacal Research
2010 Volume.33 No. 12 p.1933 ~ p.1936
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Two new triterpenoid acids from Kadsura coccinea
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Song Yan
Zhao Qing Jie
Jin Yong Sheng
Feng Chuan Wei
Chen Hai Sheng
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Abstract
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An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid (1) and 3-hydroxy-neokadsuranic acid A (2). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC50 values ranging from 3.01 to 18.08 μg/mL.
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KEYWORD
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Kadsura coccinea, Triterpenoid, Coccinic acid, Neokadsuranic acid A
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